ONCOLYTIC VIRUSES AND METHODS FOR USING ONCOLYTIC VIRUSES
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United States of America Patent
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May 12, 2022
app pub date -
Mar 12, 2020
filing date -
Mar 12, 2020
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This document relates to methods and materials for treating cancer. For example, engineered viruses (e.g., oncolytic viruses) encoding one or more inhibitors of apolipoprotein B editing complex 3B (APOBEC3B) polypeptide activity or expression and methods for using such viruses as an oncolytic agent (e.g., to treat cancer) are provided. For example, one or more engineered oncolytic viruses encoding one or more inhibitors of APOBEC3B polypeptide activity or expression can be administered to a mammal having cancer to treat that mammal.
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