METHODS AND SYSTEMS FOR CHARACTERIZING TUMOR RESPONSE TO IMMUNOTHERAPY USING AN IMMUNOGENIC PROFILE
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United States of America
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May 5, 2022
app pub date -
Oct 29, 2021
filing date -
Oct 29, 2021
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Abstract
A method for characterizing response of a tumor to immunotherapy, including: (i) obtaining tissue from the tumor; (ii) generating, from the obtained tissue, an immune gene expression dataset comprising gene expression data for a plurality of immune genes; (iii) calculating, from the immune gene expression dataset, an immunogenic signature score; (iv) identifying, based on the calculated immunogenic signature score, the tumor as strongly immunogenic, moderately immunogenic, or weakly immunogenic; and (v) predicting, based on the identification of the tumor as strongly immunogenic, moderately immunogenic, or weakly immunogenic, the response of the tumor to immunotherapy.
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