POLYETHYLENE GLYCOL-MODIFIED FORM OF HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF
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United States of America
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Issued Date -
Apr 21, 2022
app pub date -
Jan 28, 2020
filing date -
Jan 28, 2020
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Abstract
A polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof achieves both an in vivo half-life extending effect of polyethylene glycol modification and the retainment of bioactivity. The polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof has one molecule of forked-type polyethylene glycol covalently bound to two molecules of the hepatocyte growth factor or the active fragment thereof at each of their respective carboxyl-terminal regions to form a homodimer.
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