METHOD FOR IDENTIFYING MODULATORS OF G3BP ACTIVITY
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United States of America
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Issued Date -
Mar 24, 2022
app pub date -
Dec 3, 2021
filing date -
Dec 3, 2021
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Abstract
A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
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