COMBINATION THERAPIES OF EGFRVIII CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS

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United States of America

APP PUB NO 20220088075A1
SERIAL NO

17432868

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Abstract

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Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., EGFRvIII, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., EGFRvIII, in combination with a PD-1 inhibitor.

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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA3600 CIVIC CENTER BOULEVARD 9TH FLOOR PHILADELPHIA PA 19104

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bagley, Stephen Joseph Blue Bell, US 1 3
Desai, Arati Suvas Philadelphia, US 1 3
Isaacs, Randi Basking Ridge, US 5 56
O'Rourke, Donald M Wynnewood, US 14 113

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