A MULTI-COMPARTMENT DEVICE CONTAINING HUMAN THREE-DIMENSIONAL (3D) MICROTISSUES FOR TOXICITY TESTING
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United States of America
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Mar 17, 2022
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Jan 9, 2020
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Jan 9, 2020
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This dual-compartment liver co-culture system exposes target microtissue to metabolites, allowing for evaluating toxicity using a standard multi-well plate for high throughput analysis. Discovery scientists can rapidly select lead compounds with desirable metabolic profiles, while safety scientists can determine the safety of drugs, pesticides, and environmental chemicals. This platform is allometrically scalable, so it can mimic the natural size differences between healthy organs and, with the liver, produce sufficient quantities of metabolites. The device is simple to use and designed for immediate in vitro pathology assessment using confocal microscopy, transcriptomics, and proteomics.
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