QUINOLINYL-PYRAZINE-CARBOXAMIDE COMPOUNDS AND USES THEREOF
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United States of America
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Mar 17, 2022
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Dec 20, 2019
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Dec 20, 2019
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Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a quinolinyl-pyrazine-carboxamide (or similar) structure which function as activators of the cholesterol biosynthesis pathway within cancer cells and/or immune cells, which function as activators of the cell cycle regulation pathway within cancer cells and/or immune cells, and which function as up-regulators of HMGCS1 protein expression within cancer cells and/or immune cells, and which function as effective therapeutic agents for treating, ameliorating, and preventing various forms of cancer and other inflammatory disease.
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