METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS
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United States of America Patent
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Feb 17, 2022
app pub date -
Mar 29, 2021
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Mar 29, 2021
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The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells am molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described hemin are useful for treating retinal degenerative diseases.
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