HUMANISED ANTI-IL17BR ANTIBODY

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United States of America Patent

APP PUB NO 20220041740A1
SERIAL NO

17299212

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Abstract

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This invention relates to humanised versions of the murine anti-IL17BR antibody D9.2 which comprise mutations of certain residues within the heavy chain and/or light chain variable domains that display improved expression without deleterious effects on specificity or affinity. The humanised antibodies may comprise a heavy chain variable (VH) domain which comprises a VHCDR1 of SEQ ID NO: 1, a VHCDR2 of SEQ ID NO: 2, and a VHCDR3 of SEQ ID NO: 3, for example, a VH domain of SEQ ID NO: 9, SEQ ID NO: 10 or SEQ ID NO: 11. The humanised antibodies may comprise a light chain variable (VL) domain which comprises a VLCDR1 of SEQ ID NO: 4, a VLCDR2 of SEQ ID NO: 5, and a VLCDR3 of SEQ ID NO: 6, for example a VL domain of SEQ ID NO: 13. Antibodies, pharmaceutical compositions and methods of use, for example in the treatment of cancer are provided.

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Patent Owner(s)

Patent OwnerAddress
LIFEARCLONDON GREATER LONDON WC1H 9LT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Matthews, David Greater London, GB 43 271
Patel, Seema Greater London, GB 6 2

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