PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20220033518A1
SERIAL NO

17003952

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αPSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αPSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.

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Patent Owner(s)

Patent OwnerAddress
AMBRX INC10975 NORTH TORREY PINES ROAD SUITE 100 LA JOLLA CA 92037

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barnett, Richard San Marcos, US 12 418
Beck, Andrew San Diego, US 45 1819
Gymnopoulos, Marco San Diego, US 10 25
Hays, Putnam Anna-Maria A San Diego, US 36 1085
Knudsen, Nickolas Escondido, US 14 2
Sun, Ying San Diego, US 390 7529
Tian, Feng San Diego, US 160 3003

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