3D HUMAN CANCER MODEL-BASED COMBINATORIAL DRUG DEVELOPMENT METHOD
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United States of America
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Dec 23, 2021
app pub date -
Nov 20, 2019
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Nov 20, 2019
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Abstract
The present invention relates to a method of characterizing a composition comprising two or more active drug compounds, the method comprising the steps of: a) a composition selection screen (CSS), in which screen a candidate composition comprising two or more active drug compounds is tested against a 3D microtissue derived from one or more cell line, and b) a composition validation screen (CVS), in which screen the candidate composition of step b) is tested against a 3D microtissue derived from a primary patient sample.
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