N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20210395236A1
SERIAL NO

17286870

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Abstract

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The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

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Patent Owner(s)

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MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ACTON,, III John J Cranford, US 11 21
ARDOLINO, Michael J Arlington, US 2 1
CHEN, Joanna L Braintree, US 6 2
FULLER, Peter H Ashland, US 18 18
GUNAYDIN, Hakan Somerville, US 22 66
KAPLAN, William P Boston, US 4 1
LI, Derun Roxbury, US 33 47
LIU, Ping Westfield, US 587 9247
LOGAN, Kaitlyn Marie Boston, US 3 1
METHOT, Joey Westwood, US 10 102
MORRIELLO, Gregori J Randolph, US 32 389
NEELAMKAVIL, Santhosh F Edison, US 12 26
SIMOV, Vladimir South Boston, US 15 195
TORRES, Luis Norwood, US 38 245
YAN, Xin Newton, US 65 698
ZHOU, Hua Acton, US 1452 11976

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