METHOD FOR SIMULTANEOUS ANALYSIS OF NEUROTRANSMITTERS AND THEIR METABOLITES BASED ON DERIVATIZATION
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United States of America
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Issued Date -
Dec 16, 2021
app pub date -
Mar 31, 2021
filing date -
Mar 31, 2021
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Abstract
Disclosed is a method for simultaneous analysis of neurotransmitters and/or their metabolites. The method includes (a) separating analytes including a plurality of neurotransmitters and/or their metabolites from a sample selected from body tissues, body fluids, secretions, and excretions, (b) derivatizing the analytes with ethyl chloroformate to obtain derivatives of the plurality of neurotransmitters and/or their metabolites, (c) separating the derivatives of the plurality of neurotransmitters and/or their metabolites by liquid chromatography, and (d) subjecting the separated derivatives of the neurotransmitters or their metabolites to multiple reaction monitoring (MRM) using a mass spectrometer. According to the method, a plurality of neurotransmitters in a very small amount of sample can be simultaneously analyzed in an accurate and rapid manner based on derivatization to increase the stability and ionization efficiency of the substances.
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