METHOD FOR THREE-DIMENSIONAL NUCLEIC ACID IMAGING DIAGNOSIS OF TISSUE BY USING ISOTHERMAL NUCLEIC ACID AMPLIFICATION
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United States of America
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Dec 16, 2021
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Mar 28, 2019
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Mar 28, 2019
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The present invention relates to a method for three-dimensional nucleic acid imaging diagnosis of a tissue by using isothermal nucleic acid amplification. The method for three-dimensional nucleic acid imaging diagnosis of tissue according to the present invention can allow a specific molecular biomarker to be clearly seen in tissue through clearing of the tissue, enhance diagnostic accuracy by three-dimensionally reconstituting the tissue since all of the inside of the tissue is visualized, and facilitate three-dimensional imaging of a molecular biomarker such as DNA or RNA containing genetic information in the human body through isothermal nucleic acid amplification in tissue, and thus this method can be effectively used in diagnosis of various diseases including cancer.
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