CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN
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Issued Date -
Sep 30, 2021
app pub date -
Mar 26, 2021
filing date -
Nov 11, 2015
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Abstract
There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C═O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C═O— is a peptide.
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