Application of microRNA-210 inhibitor in preparation of drugs for treating inflammatory skin diseases

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United States of America Patent

PATENT NO 11542502
APP PUB NO 20210284999A1
SERIAL NO

16978778

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Abstract

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Disclosed are methods of using a microRNA-210 inhibitor in preparation of drugs for treating inflammatory skin diseases. The present inventor has demonstrated through a large number of experiments that in vitro inhibition of microRNA-210 expression can significantly enhance the expression of its target gene STAT6, thereby inhibiting proliferation and chemokine CCL20 secretion of keratinocytes, further inhibiting chemotactic T cell migration towards skin lesion, and also inhibiting differentiation of TH1 and TH17. MicroRNA-210 knockout and intradermal injection of a microRNA-210 inhibitor (cholesterol-modified antagomiR-210) on a skin lesion specifically inhibit the expression of microRNA-210, so that skin inflammation in mice can be significantly inhibited, and T cell immune imbalance is mitigated. The present invention provides a new pathophysiological mechanism for inflammatory skin diseases and provides a new strategy for preparing drugs for treating inflammatory skin diseases.

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Patent OwnerAddress
THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITYNO 139 RENMIN ROAD CHANGSHA HUNAN 410011

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lu, Qianjin Changsha, CN 8 3
Su, Yuwen Changsha, CN 17 311
Wu, Ruifang Changsha, CN 1 0
Zhao, Ming Changsha, CN 290 4711

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