Multispecific binding constructs against checkpoint molecules and uses thereof

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United States of America Patent

PATENT NO 11970538
APP PUB NO 20210284736A1
SERIAL NO

17325268

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Abstract

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The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.

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Patent Owner(s)

Patent OwnerAddress
COMPASS THERAPEUTICS LLC245 FIRST STREET 3RD FLOOR CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albu, Diana I Windham, US 3 0
Bakhru, Pearl Ashland, US 3 0
Eskiocak, Ugur Somerville, US 25 78
Gong, Bing Brighton, US 41 116
Leung, Cheuk Lun Quincy, US 16 71
Oliphant, Amanda Frank Boston, US 5 5
Rennard, Rachel Stoneham, US 5 0
Wolf, Benjamin Jacob Seattle, US 7 0

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