CONJUGATES WITH INTERNAL AND TERMINAL-END HEPAROSAN LINKAGES
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United States of America Patent
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Issued Date -
Aug 12, 2021
app pub date -
Jun 21, 2019
filing date -
Jun 25, 2018
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Abstract
Described herein are compositions such as antibody-drug conjugates that include a heparosan polymer. In some embodiments, a targeting moiety is bound to an end of the heparosan polymer or to an internal monomeric subunit of the heparosan polymer. In some embodiments, a payload molecule is bound to an end of the heparosan or to an internal monomeric subunit. Some embodiments relate to methods of making and using the compositions.
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