ENHANCEMENT OF ANTIBACTERIAL ACTIONS OF A DEPSIPEPTIDE ANTIBIOTIC USING SYNERGISTIC AMOUNTS OF BORIC ACID
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United States of America Patent
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Aug 12, 2021
app pub date -
Jun 12, 2019
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Jun 13, 2018
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Abstract
An external or topical formulation for treatment or prevention of infections involving body surfaces using a depsipeptide antibiotic drug such as lotilibcin having improved efficacy and safety is provided. The antibacterial effect of lotilibcin tested in infectious models is substantially enhanced by addition of boric acid in a low concentration of an additive level which does not produce any pharmacological activity by itself, thereby offering a formulation for external preparations having improved safety due to a decrease in dose, dosing period, and dosing frequency.
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