Crystalline forms of 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid and processes for their preparation

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United States of America Patent

PATENT NO 11584741
APP PUB NO 20210230151A1
SERIAL NO

17109758

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Abstract

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The present invention pertains generally to the field of therapeutic compounds, and more specifically to crystalline forms of 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid (referred to herein as “BHBA-001”), which, inter alia, is a (selective) retinoic acid receptor beta (RARβ) (e.g., RARβ2) agonist. The present invention also pertains to pharmaceutical compositions comprising such crystalline forms, and the use of such crystalline forms and compositions, both in vitro and in vivo, to (selectively) activate RARβ (e.g., RARβ2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RARβ (e.g., RARβ2), that are ameliorated by the activation of RARβ (e.g., RARβ2), etc., including, e.g., neurological injuries such as spinal cord injuries.

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Patent OwnerAddress
KING'S COLLEGE LONDONLONDON WC2R 2LS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aret, Edwin Weert, NL 18 64
Borthwick, Alan David London, GB 29 105
Brown, Jane Theresa Nottingham, GB 8 19
Corcoran, Jonathan Patrick Thomas London, GB 12 34
De, Castro Vasconcelos Goncalves Maria Beatriz London, GB 6 16
Kalindjian, Sarkis Barrett Bansted, GB 2 1
Lawrence, Ronnie Maxwell Stevenage, GB 17 61

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