DEVICES AND METHODS FOR A DNA DOUBLE-STRAND-BREAK DOSIMETER
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United States of America Patent
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Jul 1, 2021
app pub date -
Feb 4, 2017
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Feb 4, 2016
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Abstract
Devices and methods for detecting radiation-induced cell damage by directly measuring DNA damage resulting from delivered radiation exposure is disclosed herein. The device can measure the rate of DNA double-strand break, which is the dominant factor for radiation induced cell damage. This approach enables more accurate measurements as compared to current exposure-based dosimetry. In embodiments, the device is comprised of magnetic streptavidin beads and strands of DNA configured with a biotin on one end and fluorescein on the other.
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