Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

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United States of America Patent

PATENT NO 11161854
APP PUB NO 20210188863A1
SERIAL NO

16755172

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Abstract

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The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

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Patent Owner(s)

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MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acton, John Cranford, US 5 174
Candito, David Annunziato Wrentham, US 2 4
Chau, Ryan Wing-Kun Somerville, US 1 4
Chen, Joanna L Braintree, US 6 4
Ellis, J Michael Needham, US 12 226
Fuller, Peter H Ashland, US 18 36
Graham, Thomas H Somerville, US 43 434
Gulati, Anmol Watertown, US 13 48
Gunaydin, Hakan Somerville, US 22 132
Kattar, Solomon Wakefield, US 16 394
Keylor, Mitchell Henry Malden, US 1 4
Lapointe, Blair T Sudbury, US 19 584
Liu, Ping Westfield, US 587 18494
Liu, Weiguo Princeton, US 102 696
Methot, Joey L Westwood, US 31 388
Neelamkavil, Santhosh F Edison, US 12 52
Simov, Vladimir South Boston, US 15 390
Tong, Ling Warren, US 108 1340
Wood, Harold B Westfield, US 33 138

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