An irradiation target positioning device and method for creating radioisotopes utilizing linear particle beam accelerators or cyclotron accelerators is disclosed. The device positions a target proximate to a liquid reservoir and vapor expansion chamber. The target may be in a solid phase. Heat produced within the target during irradiation can be absorbed by the liquid. The liquid may be heated to its vaporization temperature and vapor emitted into the vapor chamber. The vapor chamber may utilize a cooling mechanism, for allowing the vapor to condense (second phase change). A radioactive product may diffuse into the liquid, thereby allowing the irradiated product to be conveyed out of the target structure in a liquid, solution, or slurry. Multiple radioisotopes may be produced simultaneously out of the target material and liquid and separated later. The target material and the irradiated product may be removed from the target surface by acid.

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