Method for reducing the expression of NKCC1 in a subject

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United States of America Patent

PATENT NO 11427836
APP PUB NO 20210130847A1
SERIAL NO

16604648

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Abstract

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An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.

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Patent Owner(s)

Patent OwnerAddress
GENETHONFRENCH EVERI EVRY ESSONNE
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)PARIS FRANCE PARIS PARIS
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA16163 GENOVA
FONDAZIONE TELETHON00185 ROMA
UNIVERSITE D'EVRY-VAL-D'ESSONNE23 BOULEVARD FRANCOIS MITTERRAND EVRY-COURCOURONNES 91000

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cancedda, Laura Genoa, IT 5 3
Contestabile, Andrea Genoa, IT 3 0
Mingozzi, Federico Paris, FR 40 273
Ronzitti, Giuseppe Paris, FR 24 41

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