Hydroxypropyl methyl cellulose acetate succinate and method for producing the same

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United States of America Patent

PATENT NO 11753483
APP PUB NO 20210130497A1
SERIAL NO

17083615

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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There is provided a method for producing hydroxypropyl methyl cellulose acetate succinate (HPMCAS), including an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; and a washing and recovery step of washing the HPMCAS in the suspension and recovering the washed HPMCAS. Further, there is provided HPMCAS having yellowness at 20° C. of 15.0 or less, as determined in a 2% by mass solution of the HPMCAS in a mixed solvent of dichloromethane, methanol and water in a mass ratio of 44:44:10.

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Patent Owner(s)

Patent OwnerAddress
SHIN-ETSU CHEMICAL CO LTDJAPAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kitaguchi, Taishi Niigata, JP 13 4
Matsubara, Junichi Niigata, JP 28 48
Yoshida, Mitsuhiro Niigata, JP 104 849

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