Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists

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United States of America Patent

PATENT NO 11401265
APP PUB NO 20210130337A1
SERIAL NO

16997855

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Abstract

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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as “BHBA compounds”), which, inter alia, are (selective) retinoic acid receptor beta (RARβ) (e.g., RARβ2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARβ (e.g., RARβ2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RARβ (e.g., RARβ2), that are ameliorated by the activation of RARβ (e.g., RARβ2), etc., including, e.g., neurological injuries such as spinal cord injuries.

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Patent Owner(s)

Patent OwnerAddress
KING'S COLLEGE LONDONLONDON WC2R 2LS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borthwick, Alan David London, GB 29 105
Brown, Jane Theresa Nottingham, GB 8 19
Corcoran, Jonathan Patrick Thomas London, GB 12 34
De, Castro Vasconcelos Goncalves Maria Beatriz London, GB 6 16
Kalindjian, Sarkis Barret Surrey, GB 25 184
Mills, Mark Trevor Nottingham, GB 4 16

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