POL6 POLYMERASE VARIANTS

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United States of America Patent

APP PUB NO 20210071152A1
SERIAL NO

17088471

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.

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Patent Owner(s)

Patent OwnerAddress
ROCHE MOLECULAR SYSTEMS INC4300 HACIENDA DRIVE PLEASANTON CALIFORNIA 94588 94588

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amato, Evan Menlo Park, US 3 0
Arnold, Cleoma San Jose, US 7 17
Ayer, Aruna Santa Clara, US 29 42
Boenitz-Dulat, Mara Tutzing, DE 24 22
Eckert, Barbara El Cerrito, US 10 14
Lederman, Ilya San Francisco, US 13 34
McGaw, Colin Santa Clara, US 3 0
Sarvabhowman, Preethi Santa Clara, US 11 8
Schwab, Charles Wayan San Ramon, US 9 31
Suko, Shawn El Sobrante, US 31 188
Thai, Eileen San Jose, US 13 34
Woersdoerfer, Bigna Muenchen, DE 8 14
Wunderlich, David Penzberg, DE 5 0

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