NANOPARTICLE DELIVERY SYSTEM FOR DISEASES ASSOCIATED WITH MAJOR BASEMENT MEMBRANE COMPONENTS OF BLOOD VESSELS ACCESSIBLE FROM BLOOD STREAM
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United States of America Patent
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Issued Date -
Mar 11, 2021
app pub date -
Nov 17, 2020
filing date -
May 31, 2018
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Abstract
A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.
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