TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF

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United States of America Patent

APP PUB NO 20210040066A1
SERIAL NO

16967721

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Abstract

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Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCESZHANGJIANG PUDONG SHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHEN, Kaixian Pudong, Shanghai, CN 52 28
CHEN, Tiantian Pudong, Shanghai, CN 4 3
CHEN, Wuyan Pudong, Shanghai, CN 1 0
DONG, Guangyu Pudong, Shanghai, CN 10 461
FENG, Chunlan Pudong, Shanghai, CN 3 36
GU, Zhanni Pudong, Shanghai, CN 1 0
HAN, Xu Pudong, Shanghai, CN 144 1189
JIANG, Hualiang Pudong, Shanghai, CN 58 37
LI, Heng Pudong, Shanghai, CN 76 82
LIU, Hong Pudong, Shanghai, CN 550 3045
TANG, Wei Pudong, Shanghai, CN 217 3421
XU, Yechun Pudong, Shanghai, CN 4 0
ZHANG, Xianglei Pudong, Shanghai, CN 3 5
ZHU, Fenghua Pudong, Shanghai, CN 4 55

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