Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose

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United States of America Patent

PATENT NO 11542309
APP PUB NO 20210032303A1
SERIAL NO

16929342

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Abstract

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The present disclosure provides FGF1 mutant proteins, which selectively bind to/activate FGFR1b. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed FGF1 mutants to reduce blood glucose in a mammal and treat a metabolic disorder are provided.

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Patent Owner(s)

Patent OwnerAddress
SALK INSTITUTE FOR BIOLOGICAL STUDIES10010 N TORREY PINES ROAD LA JOLLA CA 92037-1002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atkins, Annette San Diego, US 29 172
Downes, Michael San Diego, US 82 715
Evans, Ronald M La Jolla, US 177 3476
Liu, Sihao San Diego, US 5 2
Yu, Ruth T La Jolla, US 39 218

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