Method for preparing liposome comprising ultrasound reactive microbubble for drug delivery and liposome using same
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United States of America Patent
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Nov 22, 2022
Grant Date -
Jan 21, 2021
app pub date -
Mar 20, 2019
filing date -
Mar 20, 2018
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Abstract
Provided are a method for preparing liposomes comprising ultrasound reactive microbubbles for drug delivery, comprising (a) a step of producing ultrasound reactive microbubbles comprising an inert gas therein and having a first shell formed on the outer surface thereof, followed by forming a uniform size distribution of the ultrasound reactive microbubbles through an extruder; and (b) a step of producing liposomes comprising the ultrasound reactive microbubbles distributed in a uniform size and a medicament therein and having a second shell formed on the outer surface thereof, followed by forming a uniform size distribution of the liposomes through an extruder; and a liposome using same.
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