Methods for manufacturing T cells by direct sorting and compositions thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 12011459
APP PUB NO 20210002610A1
SERIAL NO

16893246

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Described herein are methods for preparing T cells, including isolating CD8+ T cells from a blood sample obtained from a patient or a donor, culturing the isolated CD8+ T cells in the presence of at least one cytokine, contacting the cultured CD8+ T cells with a multimer containing a target peptide in a complex with an MHC molecule and with at least one binding agent that binds to a T cell surface molecule, in which the multimer is labelled with a first detectable agent and the binding agent is labelled with a second detectable agent, sorting the contacted CD8+ T cells to collect the sorted CD8+ T cells that are detected positive for the first and the second detectable agents, and expanding the collected CD8+ T cells.

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Patent Owner(s)

  • IMMATICS US, INC.; IMMATICS BIOTECHNOLOGIES GMBH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alpert, Amir Houston, US 10 12
Maurer, Dominik Moessingen, DE 68 166
Mohamed, Ali Sugar Land, US 15 61
Smith, Anastasiya Houston, US 2 2
Wagner, Claudia Tuebingen, DE 72 274

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