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Abstract

Provided herein are methods of selecting a T cell line from among a collection of T cell lines for therapeutic administration to a human patient to treat a disease or disorder associated with a pathogen or to treat a cancer in the human patient. When the human patient has not been the recipient of any cellular transplant, the method involves excluding T cell lines restricted by only one HLA allele shared with the human patient and selecting a T cell line that is restricted to more than one HLA allele shared with the human patient and that exhibits a T cell response against an antigen of the pathogen or cancer. When the human patient has been the recipient of a cellular transplant, the method involves excluding T cell lines restricted by only one HLA allele shared with an entity selected from the group consisting of (i) the diseased cells in the human patient that express the one or more antigens of the pathogen or cancer, (ii) the human patient, (iii) the donor of the cellular transplant, and (iv) both the human patient and the donor of the cellular transplant, and selecting a T cell line that is restricted to more than one HLA allele shared with the entity and that exhibits a T cell response against an antigen of the pathogen or cancer.

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