CHARACTERIZATION OF DOMAIN-SPECIFIC CHARGE VARIANTS OF ANTIBODIES
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United States of America Patent
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Nov 26, 2020
app pub date -
May 23, 2020
filing date -
May 23, 2019
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Abstract
The present invention provides methods and systems for analyzing the biophysical characteristics of peptides or proteins, such as antibodies, based on enzymatic digestion-assisted imaged capillary electrophoresis (DiCE) to characterize the domain-specific charge variants, preferably within a bispecific antibody. The methods and systems include treating the protein with digestion enzymes to generate components of the protein, reducing or denaturing the components, and separating the components based on their isoelectric points.
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