CRYSTAL FORM OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL INHIBITOR AND PREPARATION METHOD THEREOF
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Nov 5, 2020
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Dec 5, 2018
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Dec 6, 2017
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The present invention provides a crystal form of a renal outer medullary potassium channel inhibitor and a preparation method thereof. In particular, the present invention provides crystal form III of a L-tartrate of a renal outer medullary potassium channel (ROMK) inhibitor (I) and a preparation method thereof. The crystal form III has good chemical stability and crystal form stability, and the crystallization solvent used has low toxicity and residue. Thus, the present invention can be better used in clinical treatment.
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