Bioengineered in vitro 3D model of human atherosclerotic plaque
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United States of America Patent
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Apr 2, 2024
Grant Date -
Oct 15, 2020
app pub date -
Aug 23, 2018
filing date -
Aug 23, 2017
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Abstract
The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.
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