METHOD FOR QUANTIFYING PROTEIN AGGREGATES OF A PROTEIN MISFOLDING DISEASE IN A SAMPLE
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United States of America Patent
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Issued Date -
Oct 8, 2020
app pub date -
Oct 25, 2018
filing date -
Nov 23, 2017
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Abstract
Provided herein is a method for quantifying protein aggregates of a protein misfolding disease in a sample, comprising: placing a capture molecule A on a substrate; selecting a complex sample comprising an aggregate of the protein misfolding disease; removing insoluble components from the sample; contacting the sample with capture molecule A on a part of the substrate; contacting a calibration standard with the capture molecule A on another part of the substrate, contacting at least one capture molecule B with both the aggregate of the sample and the calibration standard, wherein the capture molecule B can emit a detectable signal; comparing the signals of the at least one capture molecule B arranged on the sample assembly and on the calibration standard, wherein the steps do not have to be carried out successively. A related device, kit, and method for detecting protein aggregates are also provided.
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