Kinase inhibitor compounds and compositions and methods of use
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United States of America Patent
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Jan 10, 2023
Grant Date -
Oct 1, 2020
app pub date -
Nov 20, 2018
filing date -
Nov 20, 2017
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Abstract
The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
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