TREATMENT OF BONE GROWTH DISORDERS
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United States of America Patent
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Jul 23, 2020
app pub date -
Sep 28, 2016
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Sep 28, 2015
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Abstract
The present invention relates to an activator of beclin 1-Vps 34 complex for use in the treatment and/or prevention of a bone growth disorder. The activator may be a polypeptide, a polynucleotide, a vector, a host cell or a small molecule. In particular the activator may be a Beclin 1 peptide or a fragment or a derivative thereof, a mTORC1 inhibitor or a BH3 mimetic. The present invention also relates to pharmaceutical composition comprising said activator.
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