COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS
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United States of America Patent
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Issued Date -
Jul 23, 2020
app pub date -
Aug 8, 2018
filing date -
Aug 25, 2017
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Abstract
Nanoparticles and microspheres are provided for delivering an anticancer agent or other active agents to a subject. The nanoparticles and the microspheres are formed from a core that is encased by a coating or shell that includes a somatostatin-albumin fusion protein or analogue thereof. The somatostatin-albumin fusion protein includes at least one albumin (or an analog thereof) moiety, at least one somatostatin moiety (e.g. SST-14, SST-28), and at least one spacer connecting albumin to albumin, somatostatin to somatostatin and/or albumin to somatostatin moieties.
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