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Abstract

Disclosed are a nanocone structure composite material for capturing cancer cells, a preparation method therefor and the use thereof, which belong to the technical field of medical biomaterials. The method comprises: firstly, electrodepositing a chlorine-doped polypyrrole on the surface of a conductive substrate by using chronoamperometry; then, using chronopotentiometry and selecting a three-electrode mode with a conductive metal as a counter electrode, the conductive substrate deposited with the polypyrrole as a working electrode, and a buffer solution containing pyrrole and biotin as an electrolyte to deposit a nanocone structure polypyrrole/biotin material onto the working electrode; and finally, subjecting the working electrode deposited with the nanocone structure polypyrrole/biotin material to an activation treatment, placing the working electrode in a streptavidin solution for culturing, subjecting the working electrode to a grafting reaction with an antibody, and culturing the working electrode in a BSA solution to obtain a nanocone structure composite material. The method is simple and has low cost; and the nanocone structure in the composite material is stable and can better capture cancer cells and non-destructively release the cancer cells.

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