STABLE INTEGRATION OF SIN TRANFER VECTORS
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United States of America Patent
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May 28, 2020
app pub date -
Dec 20, 2016
filing date -
Dec 21, 2015
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Abstract
The present invention relates to the field of the production of lentiviral vectors (LV) for gene therapy. More particularly, the invention relates to a system to obtain the stable integration of a Self Inactivating (SIN) lentiviral transfer vector into a packaging cell line. The SIN lentiviral transfer vector is integrated using a DNA fragment containing the Inverted Terminal Repeats (ITR) of Adeno Associated Virus (AAV), thus obtaining the stable producer cell line for SIN lentiviral vectors.
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