Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof

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United States of America Patent

PATENT NO 11124563
APP PUB NO 20200165329A1
SERIAL NO

16700788

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Abstract

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The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.

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Patent Owner(s)

Patent OwnerAddress
F HOFFMANN-LA ROCHE AGBASEL SUI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bay, Sylvie Paris, FR 18 51
Czech, Christian Grenzach-wyhlen, DE 12 63
Delatour, Benoit Cachan, FR 5 15
Dhenain, Marc Limours, FR 5 15
Duyckaerts, Charles Saint-mandé, FR 6 15
Grueninger, Fiona Arlesheim, CH 18 159
Lafaye, Pierre Malakoff, FR 21 59
Li, Tengfei Courbevoie, FR 23 67
Vandesquille, Matthias Fontenay-aux-roses, FR 5 15

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