USE OF THE IL-15/IL-15RA COMPLEX IN THE GENERATION OF ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE IMMUNOTHERAPY
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May 21, 2020
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May 25, 2017
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May 25, 2017
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Provided herein are methods of generating antigen-specific T cells for therapeutic administration to a human patient having or suspected of having a pathogen or cancer, utilizing soluble IL-15/IL-15Rα complexes ex vivo, in cell culture during ex vivo sensitizing of T cells to the antigen or during ex vivo culturing of antigen-specific T cells. Also disclosed are antigen-specific T cells generated by such methods, and methods of treating a human patient using such antigen-specific T cells. Cell culture systems comprising human T cells, antigen-presenting cells, and soluble IL-15/IL-15Rα complexes are also provided.
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