DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-LGR7 ANTIBODY

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United States of America Patent

APP PUB NO 20200157231A1
SERIAL NO

16782728

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Abstract

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With dedicated research, the present inventors discovered that not only the LGR7 gene but also the LGR7 protein are highly expressed in clear cell adenocarcinoma cells of ovarian cancer. Furthermore, the present inventors found that anti-LGR7 antibodies have antibody-dependent cell-mediated cytotoxicity (ADCC) activity and complement-dependent cytotoxicity (CDC) activity against LGR7-expressing cells. From the above findings, the present inventors discovered that the anti-LGR7 antibodies are useful for diagnosis, prevention, and treatment of primary and metastatic ovarian clear cell adenocarcinoma.

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Patent Owner(s)

Patent OwnerAddress
CHUGAI SEIYAKU KABUSHIKI KAISHA5-1 UKIMA 5-CHOME KITA-KU TOKYO 1158543 ?1158543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ABURATANI, Hiroyuki Tokyo, JP 60 599
FUNAHASHI, Shinichi Tokyo, JP 6 45
UEHARA, Yuriko Tokyo, JP 3 62

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