Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof

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United States of America Patent

PATENT NO 11472863
APP PUB NO 20200157185A1
SERIAL NO

16604081

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Abstract

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A hyperglycosylated recombinant human coagulation factor IX (FIX) fusion protein, a preparation method therefor, and use thereof. The fusion protein sequentially comprises, from N- to C-terminus, a human FIX, a flexible peptide linker, at least one human chorionic gonadotropin β subunit carboxy-terminal peptide rigid unit, and a half-life extending moiety. The fusion protein has a biological activity similar to that of the recombinant FIX, an extended in vivo activity half-life, and reduced immunogenicity, so as to improve pharmacokinetics and pharmacodynamics.

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Patent Owner(s)

Patent OwnerAddress
PHARMAB INCROOM 315 NO 518 BIBO ROAD PUDONG NEW AREA SHANGHAI 201203
AMPSOURCE BIOPHARMA SHANGHAI INCSHANGHAI 201318

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Si Shanghai, CN 149 779
Gao, YongJuan Shanghai, CN 8 22
Li, Qiang Shanghai, CN 872 12045
Li, Zirui Shanghai, CN 8 279
Sun, Bill Nai-chau Shanghai, CN 6 27
Tu, Xiaoping Shanghai, CN 3 7

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