Crystal characteristics, preparation processes and anticancer applications of 17beta-neriifolin crystal forms

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United States of America Patent

PATENT NO 11091510
APP PUB NO 20200157139A1
SERIAL NO

16688169

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The present invention provides the preparation processes for several crystal forms of the compound 17beta-Neriifolin (17bNF) and use thereof in anti-tumor applications. The present invention provides preparation processes for four kinds of non-solvated crystal forms, amorphous powders and eleven kinds of solvated crystalline solids, including ethanol-solvated ones, of 17bNF that are not present in nature, and the identification and characterization of these crystal forms by crystallographic research methods such as X-ray powder diffraction. In addition, through vivo anti-tumor experiments with five of the crystal forms in nude mice, we provide anti-tumor and anti-cancer applications of the crystal forms of 17bNF.

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ENKANG PHARMACEUTICALS (GUANGZHOU) LTD5TH FLOOR BLOCK 4C UNIT 2 NO 9 LUOXUAN 4TH ROAD GUANGZHOU INTERNATIONAL BIO-ISLAND GUANGZHOU GUANGDONG 510000 510000
FOSHAN INTELGEN PHARMACEUTICAL CO LTD4TH FLOOR BLOCK B CLUSTER I PHASE I GUANGDONG BIOMEDICAL & TECHNOLOGY INDUSTRIAL BASE NANHAI FOSHAN GUANGDONG FOSHAN 528253
ENZYNOMICS (H K ) LIMITEDUNIT A 20/F WINSAN TOWER 98 THOMSON ROAD WANCHI HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Yushan Guangzhou, CN 35 741
Liang, Chun Guangzhou, CN 7 6
Liu, Haibin Guangzhou, CN 49 141
Song, Guoqiang Guangzhou, CN 1 0
Zhang, Weiqiang Guangzhou, CN 79 325
Zhang, Zeming Guangzhou, CN 6 9

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