HYBRID EXOSOMAL-POLYMERIC (HEXPO) NANO-PLATFORM FOR DELIVERY OF RNAI THERAPEUTICS
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United States of America
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Mar 5, 2020
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Dec 8, 2017
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Dec 8, 2017
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Provided herein are lipid-based nanoparticles (e.g., exosomes) having (a) a core comprising a cationic polymer and a therapeutic agent (e.g., a therapeutic protein, an antibody, an inhibitory RNA, and/or a small molecule drug) and (b) a lipid coating comprising an exosomes-derived membrane. Furthermore, the present invention provides methods of producing such nanoparticles as well as methods for use of such lipid-based nanoparticles in therapy.
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