ZINC BINUCLEAR CLUSTER TRANSCRIPTIONAL REGULATOR-DEFICIENT STRAIN
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United States of America
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Feb 27, 2020
app pub date -
Mar 12, 2018
filing date -
Mar 12, 2018
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Abstract
The present disclosure relates to a mutant filamentous fungal host cell which is deficient in the zinc binuclear cluster transcriptional regulator oreR or in a functional homologue thereof if compared with a parent filamentous fungal host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant filamentous fungal host cell according to the disclosure is used in a method to produce a compound of interest by microbial fermentation, for example an enzyme, substantially no oxalic acid is produced extracellularly by the cell during the fermentation as a by-product, which allows a more economical and efficient recovery of the compound of interest from the fermentation broth.
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