Processes for the Preparation of Acalabrutinib and Intermediates Thereof
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United States of America
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Feb 13, 2020
app pub date -
Apr 17, 2018
filing date -
Apr 17, 2018
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Abstract
The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
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